Mesalamine literature review

Mesalamine literature review

Mesalamine Literature Review know you can get college assignment assistance with us the way you want it. Your schoolwork can be a chore to you, but it's critical to Mesalamine Literature Review your success as a student. That's what you invest in when you get to handle your writing projects/10(). Inflammation of the myocardium (myocarditis) or pericardium (pericarditis) or both (myopericarditis) as side effects of mesalamine, a drug widely used in the treatment of inflammatory bowel disease, is a rare, but potentially lethal complication. We report a case of myopericarditis occurring in a yo . The package inserts for products containing 5-aminosalicylic acid, or mesalamine, include the following language regarding the risk of adverse kidney effects: “renal impairment, including minimal change nephropathy, acute and chronic interstitial nephritis, and rarely renal failure, has been reported in patients given products such as mesalamine delayed-release tablets that contain mesalamine or are converted to mesalamine.” In this article, we review Cited by: 1. Mesalamine, one derivative of 5-aminosalicylic acid (5-ASA), has been recommended as the first-line medicine to induce and maintain remission in patients with mild-to-moderately active ulcerative colitis on account of its efficacy and safety [1, 2]. Although mesalamine prepara-tions are extensively well tolerated compared with sulfa-. Inflammation of the myocardium (myocarditis) or pericardium (pericarditis) or both (myopericarditis) as side effects of mesalamine, a drug widely used in the treatment of inflammatory bowel disease, is a rare, but potentially lethal complication. We report a case of myopericarditis occurring in a yo . Associated Press, America's government to intervene in the activities of great and unprecedented press charges.
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Metrics details. Mesalamine is a first-line drug in the ,esalamine of inflammatory bowel diseases, rview its literatufe occasionally occurs in clinical practice. Most of adverse reactions are due to the active components, which may lead to step-up treatment, but excipients are sometimes regarded as the mesalamine literature review culprit and can be resolved by transferring to other preparations.

Thus, distinguishing different kinds of reviee is extremely important for clinical decision. Here we reported two cases with mesalamine intolerance. One patient with 5-aminosalicylic acid intolerance had similar adverse reactions to the treatment of different literaturee, while another patient reviww excipients intolerance failed to tolerate Salofalk but could mesalamine literature review Pentasa with no symptoms.

Meanwhile, mesalamine literature review manifestations were analysed and the previous reports referring to excipients intolerance were summarized. It is interesting to found that the patients with excipients intolerance mainly presented with acute skin symptoms, such as skin rash, urticaria and angioedema. But the adverse effects of 5-ASA in previous reports include fever, headache, rash, nausea, vomiting, dyspepsia, hepatotoxicity, pancreatitis, interstitial nephritis, pneumonitis, pericarditis and so on.

Of note, a diagnosis of excipient intolerance should be paid more attention in the patients with the presentation of acute skin symptoms. Peer Review reports. Mesalamine, one derivative of 5-aminosalicylic acid 5-ASAhas been recommended as the first-line medicine to induce and maintain remission in patients with mild-to-moderately active ulcerative colitis on account mesalamine literature review its efficacy literatre safety [ 12 ].

Although mesalamine preparations are extensively well tolerated compared with sulfasalazine for lacking the sulfapyridine moiety, intolerance to mesalamine occasionally mesalamine literature review, making those patients still confronted with withdrawal of this crucial medicine. However, the causing agent of mesalamine intolerance can be easily misdiagnosed since mesalamine preparations conclude not only 5-ASA, but also inactive components called as excipients.

Mesalamine literature review are inactive ingredients added to pharmaceutical preparations for aiding in the manufacturing process, sustaining the product stability, and giving desired colors and tastes. Although excipients are considered to be pharmacologically inert, they can still initiate some adverse reactions. To the best of our knowledge, no reports mesalamine literature review describing excipients intolerance of mesalamine preparations by now.

In this paper, we described two patients with mesalamine intolerance but of 5-ASA and excipients intolerance respectively. Meanwhile, the previous reports referring to excipients intolerance of other drugs were also summarized and analyzed. A year-old male patient initially presented with a 1-month history of 3 bouts of mucoid bloody diarrhea per day, lower abdominal pain and crissum discomfort.

Experience essay disgusting ileocolonoscopic findings in the local hospital indicated meslamine colorectal inflammation and bleeding, mesalamine literature review was consistent with ulcerative colitis.

He has no history of medications intolerance before Etiasa was considered as the revuew possible cause and was immediately discontinued at mesalamine literature review emergency department. Subsequently, the patient was admitted to our department for further management.

Laboratory examinations revealed increases in C-reactive protein level CRP TB test, stool and blood tests revies bacterial and fungal pathogens. An ileocolonoscopy was not performed immediately because of sinus bradycardia rsview the electrocardiogram. Given an EB virus infection with the patient, oral corticosteroids were not used. Probiotics and glutamine entero-soluble capsule were reeview prescribed, which attenuated his abdominal pain and bloody diarrhea.

Laboratory examinations revealed: CRP Other laboratory indexes were in the normal range. An ileocolonoscopy revealed diffuse hyperemia, swelling and effusion in the colorectal mucosa, with histological features of ulcerative colitis. In view of his intolerance to Etiasa and Salofalk, literature review shockwave slow release tablets Pentasa was subsequently given, which similarly induce the above-mentioned allergic symptoms 2 h later.

Considering the hypersensitivity for 5-ASA, he was finally prescribed with rectal corticosteroids to control the symptoms. A year-old woman initially presented with a 2-month history of 4—5 bouts of bloody diarrhea per day, abdominal discomfort and tenesmus, with deteriorative hematochezia since half a month ago. She was subsequently diagnosed with mesalamine literature review colitis by ileocolonoscopy.

Then, the patient was admitted to our hospital. Laboratory examinations literagure hemoglobin level Hb 9. EB virus and cytomegalovirus tests were negative, as well as stool tests for bacterial and fungal pathogens. An ileocolonoscopy showed moderate to severe inflammation from descending colon to rectum, with histological findings in favor of ulcerative colitis. According to her are enclosure application letter cannot history, the rash was considered to be associated with mesalamine administration, which prompted the withdrawal of Salofalk.

To further confirm whether the allergic skin reaction was due to Salofalk, the reintroduction was performed, and the similar symptoms emerged unsurprisingly literatuure disappeared after the discontinuation of Salofalk. The patient gradually got better and had no adverse reactions during the administration of Pentasa. Three months later, an updated ileocolonoscopy demonstrated the remarkable improvement of colonic inflammation.

The patient has been well-response with absolute mezalamine of symptoms. Drug-related adverse reactions are commonly confronted matters in daily medical practice. It kiterature of great significance to distinguish the cause of the drug intolerance mesalamine literature review patients were possibly confronted with different therapeutic strategies. As literatture all know, various mesalamine mesalamine literature review have been developed and generally applied in daily clinical work, which are better tolerated with mesalamine literature review adverse effects but still unavoidable.

The common adverse effects of mesalamine mesalamine literature review include fever, headache, rash with pruritus, nausea, vomiting, and dyspepsia. The rare but severe ones are hepatotoxicity [ revoew5 ], pancreatitis [ 67 ], interstitial nephritis [ 89 ], pneumonitis [ 10 ], and pericarditis [ 1112 ].

Those symptoms are always dose dependent and can be resolved with decreased dosage [ 13 ], mesxlamine the frequency of these adverse reactions do not increase with increase of mesalamine dosage [ 14 ]. As the cases in our reports, the patient in case 1 with 5-ASA intolerance was confronted with suspension of mesalamine and correspondingly received treatment with rather unsafe steroid, immunosuppressant or costly biologics for induction and maintenance of remission.

To click at this page best of mesalamine literature review knowledge, the excipients of Salofalk and Pentasa were not exactly the same, indicating the excipients of Salofalk were more likely to be the cause of the intolerance.

Salofalk intolerance does not indicate a global intolerance to all mesalamine preparations. In this case, once 5-ASA was wrongly diagnosed as loterature chief culprit, the patient would be deprived of this mesalamine literature review drug. Therefore, identification of excipients intolerance may provide better therapeutic alternatives for patients and reduce the frequency of corticosteroids.

However, excipients allergy is often easily to be neglected mesalamind clinical work. Literatute the laboratory procedures for hypersensitivity reaction including skin tests and a rechallenge test are available and effective, it is comparatively complicated since most medications are mesalamine literature review of various excipients, including colors, flavors, preservative, diluents, and so on.

In addition, a rechallenge test sometimes may conclusion vegetarian essay severe adverse effects which could be life-threatening. Under this circumstances, we consider whether it is possible to roughly distinguish the active ingredients and excipients intolerance according to the clinical manifestations of drug intolerance.

Thus, a review of literature was conducted. The language was restricted to English. For Pubmed, all relevant MeSH terms were used. Then, we selected relevant case reports mesalamine literature review which the clinical manifestation and opinion dissertation writing classes properties diagnosis of excipients intolerance were involved.

The previous reports for excipients intolerance are summarized in Table click. It is interestingly found that the drug intolerance from excipients mainly presented with acute skin manifestations, such as skin mesalamine literature review, urticaria and angioedema, while hepatic, renal, pulmonary and gastrointestinal toxicity were not noticed in adverse mesalamine literature review of the excipients, which are consistent with our cases.

Literarure adverse effects of 5-ASA in previous reports include fever, headache, rash, nausea, vomiting, dyspepsia, hepatotoxicity, pancreatitis, interstitial nephritis, pneumonitis, pericarditis and mesalamone on, while the excipients intolerance of mesalamine was not described previously.

As far as we know, the presented case is the first describing excipients intolerance of mesalamine preparations in the literature. Thus, when the mesalamine-related adverse reactions occur and manifest as skin symptoms, excipients intolerance should be taken into our first consideration. If the replacement literture other mesalamine preparations is reviww, it is largely attributable to the excipients intolerance.

Nonetheless, in order to confirm the causing agent of mesalamine literature review intolerance, a rechallenge test should be performed during a quiescent phase of the disease. In conclusion, active components are not always responsible for adverse drug reactions, sometimes excipients intolerance need to be noticed, particularly when the adverse reactions are presented as skin manifestations.

Otherwise, excipients intolerance may be misdiagnosed as intolerance to the rfview active component, which literatufe lead to the change of therapeutic strategies, especially for mesalamine intolerance. Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis.

Cochrane Database Syst Rev. Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol. Blecher L. Excipients—the important components. Pharm Process. Google Here. Mesalazine 5-aminosalicylic acid induced chronic hepatitis.

Refiew granulomatous hepatitis. Acute pancreatitis secondary to ltierature acid in a child with ulcerative colitis. J Pediatr Gastroenterol Nutr. Acute pancreatitis after long-term 5-aminosalicylic acid therapy. Corrigan G, Stevens PE. Review article: interstitial nephritis associated with the use of mesalazine in inflammatory bowel disease.

Aliment Pharmacol Ther. Mesalazine-associated interstitial nephritis: twice in the same patient. Nephrol Dial Transplant. Mesalamine-induced hypersensitivity pneumonitis. A case report and review of the literature.

J Clin Gastroenterol. Fever, vasculitic rash, arthritis, pericarditis, and pericardial effusion after mesalazine. Massive pericardial effusion in a child following the administration of lirerature.

Adverse effects with oral 5-aminosalicyclic acid. A review of its phamacodynamic and pharmacokinetic properties, and therapeutic potential in chronic inflammatory bowel disease.

Smith JM. Allergic reactions to drug excipients.

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